GABAB receptors suppress burst-firing in reticular thalamic neurons
نویسندگان
چکیده
منابع مشابه
Burst firing of neurons in the thalamic reticular nucleus during locomotion.
This study examined the burst firing of neurons in the motor sector of the thalamic reticular nucleus (RE) of the cat. These neurons are inhibitory cells that project to the motor thalamus. The firing activity of RE neurons was studied during four behaviors: sleep, standing, walking on a flat surface, and accurate stepping on crosspieces of a horizontal ladder. Extracellularly recorded firing a...
متن کاملA novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus.
The inhibitory GABAergic projection of thalamic nucleus reticularis (nRt) neurons onto thalamocortical relay cells (TCs) is important in generating the normal thalamocortical rhythmicity of slow wave sleep, and may be a key element in the production of abnormal rhythms associated with absence epilepsy. Both TCs and nRt cells can generate prominent Ca(2+)-dependent low-threshold spikes, which ev...
متن کاملGlutamate inhibits thalamic reticular neurons.
Activation of metabotropic glutamate receptors (mGluRs) can result in long-lasting modulation of neuronal excitability. Multiple mGluR subtypes are localized within the rat thalamic reticular nucleus (TRN), and we have examined the effects of activating these different receptor subtypes on the excitability of these neurons using an in vitro slice preparation. Typical of most mGluR-sensitive pre...
متن کاملTringham and Suppress Absence Seizures T - Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing
to the more complicated human condition. Further studies will be needed to determine whether its marked effects in the rat model of absence epilepsy translate Given its in vitro and in vivo activities, Z944 will progress to phase 1 clinical studies to test its safety in humans. duration and cycle frequency. Both compounds were well tolerated in rats. contrast to current first-line drugs for tre...
متن کاملAttentional modulation of thalamic reticular neurons.
The major pathway for visual information reaching cerebral cortex is through the lateral geniculate nucleus (LGN) of the thalamus. Acting on this vital relay is another thalamic nucleus, the thalamic reticular nucleus (TRN). This nucleus receives topographically organized collaterals from both thalamus and cortex and sends similarly organized projections back to thalamus. The inputs to the TRN ...
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ژورنال
عنوان ژورنال: Channels
سال: 2017
ISSN: 1933-6950,1933-6969
DOI: 10.1080/19336950.2017.1358836